3OE0
Crystal structure of the CXCR4 chemokine receptor in complex with a cyclic peptide antagonist CVX15
Summary for 3OE0
Entry DOI | 10.2210/pdb3oe0/pdb |
Related | 3ODU 3OE6 3OE8 3OE9 |
Related PRD ID | PRD_001107 |
Descriptor | C-X-C chemokine receptor type 4, Lysozyme Chimera, Polyphemusin analog, CXC chemokine receptor antagonist (3 entities in total) |
Functional Keywords | structural genomics, psi-2, protein structure initiative, accelerated technologies center for gene to 3d structure, atcg3d, 7tm, g protein-coupled receptor, gpcr, signal transduction, hydrolase, cancer, hiv-1 co-receptor, chemokine, cxcl12, chimera, t4l fusion, membrane protein, transmembrane, antimicrobial, antibiotic, polyphemusin, signaling protein, hydrolase-antibiotic complex, psi-biology, gpcr network, hydrolase/antibiotic |
Biological source | Homo Sapiens More |
Cellular location | Cell membrane; Multi-pass membrane protein: P61073 |
Total number of polymer chains | 2 |
Total formula weight | 58825.04 |
Authors | Wu, B.,Mol, C.D.,Han, G.W.,Katritch, V.,Chien, E.Y.T.,Liu, W.,Cherezov, V.,Stevens, R.C.,Accelerated Technologies Center for Gene to 3D Structure (ATCG3D),GPCR Network (GPCR) (deposition date: 2010-08-12, release date: 2010-10-27, Last modification date: 2023-11-15) |
Primary citation | Wu, B.,Chien, E.Y.,Mol, C.D.,Fenalti, G.,Liu, W.,Katritch, V.,Abagyan, R.,Brooun, A.,Wells, P.,Bi, F.C.,Hamel, D.J.,Kuhn, P.,Handel, T.M.,Cherezov, V.,Stevens, R.C. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science, 330:1066-1071, 2010 Cited by PubMed: 20929726DOI: 10.1126/science.1194396 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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