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3OE0

Crystal structure of the CXCR4 chemokine receptor in complex with a cyclic peptide antagonist CVX15

Summary for 3OE0
Entry DOI10.2210/pdb3oe0/pdb
Related3ODU 3OE6 3OE8 3OE9
Related PRD IDPRD_001107
DescriptorC-X-C chemokine receptor type 4, Lysozyme Chimera, Polyphemusin analog, CXC chemokine receptor antagonist (3 entities in total)
Functional Keywordsstructural genomics, psi-2, protein structure initiative, accelerated technologies center for gene to 3d structure, atcg3d, 7tm, g protein-coupled receptor, gpcr, signal transduction, hydrolase, cancer, hiv-1 co-receptor, chemokine, cxcl12, chimera, t4l fusion, membrane protein, transmembrane, antimicrobial, antibiotic, polyphemusin, signaling protein, hydrolase-antibiotic complex, psi-biology, gpcr network, hydrolase/antibiotic
Biological sourceHomo Sapiens
More
Cellular locationCell membrane; Multi-pass membrane protein: P61073
Total number of polymer chains2
Total formula weight58825.04
Authors
Primary citationWu, B.,Chien, E.Y.,Mol, C.D.,Fenalti, G.,Liu, W.,Katritch, V.,Abagyan, R.,Brooun, A.,Wells, P.,Bi, F.C.,Hamel, D.J.,Kuhn, P.,Handel, T.M.,Cherezov, V.,Stevens, R.C.
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.
Science, 330:1066-1071, 2010
Cited by
PubMed: 20929726
DOI: 10.1126/science.1194396
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.9 Å)
Structure validation

217705

数据于2024-03-27公开中

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