3OE0

Crystal structure of the CXCR4 chemokine receptor in complex with a cyclic peptide antagonist CVX15

3OE0 の概要

• エントリーDOI: 10.2210/pdb3oe0/pdb
• 関連するPDBエントリー: 3ODU 3OE6 3OE8 3OE9
• 関連するBIRD辞書のPRD_ID: PRD_001107
• 分子名称: C-X-C chemokine receptor type 4, Lysozyme Chimera, Polyphemusin analog, CXC chemokine receptor antagonist (3 entities in total)
• 機能のキーワード: structural genomics, psi-2, protein structure initiative, accelerated technologies center for gene to 3d structure, atcg3d, 7tm, g protein-coupled receptor, gpcr, signal transduction, hydrolase, cancer, hiv-1 co-receptor, chemokine, cxcl12, chimera, t4l fusion, membrane protein, transmembrane, antimicrobial, antibiotic, polyphemusin, signaling protein, hydrolase-antibiotic complex, psi-biology, gpcr network, hydrolase/antibiotic
• 由来する生物種: Homo Sapiens; 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P61073
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58825.04

構造登録者

Wu, B.,Mol, C.D.,Han, G.W.,Katritch, V.,Chien, E.Y.T.,Liu, W.,Cherezov, V.,Stevens, R.C.,Accelerated Technologies Center for Gene to 3D Structure (ATCG3D),GPCR Network (GPCR) (登録日: 2010-08-12, 公開日: 2010-10-27, 最終更新日: 2023-11-15)

• 主引用文献: Wu, B.,Chien, E.Y.,Mol, C.D.,Fenalti, G.,Liu, W.,Katritch, V.,Abagyan, R.,Brooun, A.,Wells, P.,Bi, F.C.,Hamel, D.J.,Kuhn, P.,Handel, T.M.,Cherezov, V.,Stevens, R.C.; Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.; Science, 330:1066-1071, 2010; PubMed: 20929726; DOI: 10.1126/science.1194396

実験手法

X-RAY DIFFRACTION (2.9 Å)