3ODV

X-ray structure of kaliotoxin by racemic protein crystallography

3ODV の概要

• エントリーDOI: 10.2210/pdb3odv/pdb
• 分子名称: Potassium channel toxin alpha-KTx 3.1, trifluoroacetic acid, CITRIC ACID, ... (4 entities in total)
• 機能のキーワード: racemic protein, direct methods, toxin, chemical synthesis
• 由来する生物種: Androctonus mauretanicus mauretanicus (Scorpion)
• 細胞内の位置: Secreted: P24662
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 8942.40

構造登録者

Pentelute, B.L.,Mandal, K.,Gates, Z.P.,Sawaya, M.R.,Yeates, T.O.,Kent, S.B.H. (登録日: 2010-08-11, 公開日: 2010-10-20, 最終更新日: 2024-10-16)

主引用文献

Pentelute, B.L.,Mandal, K.,Gates, Z.P.,Sawaya, M.R.,Yeates, T.O.,Kent, S.B.
Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography.
Chem.Commun.(Camb.), 46:8174-8176, 2010

PubMed Abstract: Here we report the total synthesis of kaliotoxin by 'one pot' native chemical ligation of three synthetic peptides. A racemic mixture of D- and L-kaliotoxin synthetic protein molecules gave crystals in the centrosymmetric space group P1 that diffracted to atomic-resolution (0.95 Å), enabling the X-ray structure of kaliotoxin to be determined by direct methods.

PubMed: 20877851
DOI: 10.1039/c0cc03148h

実験手法

X-RAY DIFFRACTION (0.95 Å)