3OCB

Akt1 kinase domain with pyrrolopyrimidine inhibitor

Summary for 3OCB

Entry DOI	10.2210/pdb3ocb/pdb
Descriptor	v-akt murine thymoma viral oncogene homolog 1 (AKT1), GSK 3 beta peptide, (2S)-2-(4-chlorobenzyl)-3-oxo-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl]propan-1-amine, ... (4 entities in total)
Functional Keywords	serine-threonine kinase, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	81978.16
Authors	Morales, T.H.,Vigers, G.P.A.,Brandhuber, B.J. (deposition date: 2010-08-09, release date: 2010-09-15, Last modification date: 2011-07-13)
Primary citation	Blake, J.F.,Kallan, N.C.,Xiao, D.,Xu, R.,Bencsik, J.R.,Skelton, N.J.,Spencer, K.L.,Mitchell, I.S.,Woessner, R.D.,Gloor, S.L.,Risom, T.,Gross, S.D.,Martinson, M.,Morales, T.H.,Vigers, G.P.,Brandhuber, B.J. Discovery of pyrrolopyrimidine inhibitors of Akt. Bioorg.Med.Chem.Lett., 20:5607-5612, 2010 Cited by PubMed: 20810279 DOI: 10.1016/j.bmcl.2010.08.053 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation