3OC1

Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding

Summary for 3OC1

• Entry DOI: 10.2210/pdb3oc1/pdb
• Related: 3MGY 3MH0 3MH1 3MH2 3MH3 3O8P 3O8T 3O8U 3OBG 3OBJ
• Descriptor: Mitogen-activated protein kinase 14, 1-(5-TERT-BUTYL-2-METHYL-2H-PYRAZOL-3-YL)-3-(4-CHLORO-PHENYL)-UREA, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: transferase
• Biological source: Homo sapiens
• Cellular location: Cytoplasm (By similarity): Q16539
• Total number of polymer chains: 1
• Total formula weight: 41621.93

Authors

Namboodiri, H.V.,Karpusas, M.,Bukhtiyarova, M.,Springman, E.B. (deposition date: 2010-08-09, release date: 2010-08-25, Last modification date: 2023-09-06)

• Primary citation: Namboodiri, H.V.,Springman, E.B.,Karpusas, M.,Bukhtiyarova, M.,Ramcharan, J.; Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding; To be Published,

Experimental method

X-RAY DIFFRACTION (2.59 Å)