3OAG

Design and optimization of new piperidines as renin inhibitors

3OAG の概要

• エントリーDOI: 10.2210/pdb3oag/pdb
• 関連するPDBエントリー: 3O9L 3OAD 3OEC
• 分子名称: Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose, (3R,4S)-N-{2-chloro-5-[(cyclopropylamino)methyl]benzyl}-N-cyclopropyl-4-{6-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]pyridin-3-yl}piperidine-3-carboxamide, ... (5 entities in total)
• 機能のキーワード: hydrolase, protease, glycosilation, blood, hydrolase - hydrolase inhibitor complex, hydrolase / hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P00797 P00797
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 77069.55

構造登録者

Prade, L. (登録日: 2010-08-05, 公開日: 2010-11-03, 最終更新日: 2020-07-29)

• 主引用文献: Corminboeuf, O.,Bezencon, O.,Grisostomi, C.,Remen, L.,Richard-Bildstein, S.,Bur, D.,Prade, L.,Hess, P.,Strickner, P.,Fischli, W.,Steiner, B.,Treiber, A.; Design and optimization of new piperidines as renin inhibitors.; Bioorg.Med.Chem.Lett., 20:6286-6290, 2010; PubMed: 20843686; DOI: 10.1016/j.bmcl.2010.08.086

実験手法

X-RAY DIFFRACTION (2.3 Å)