3O99

Crystal Structure of wild-type HIV-1 Protease in complex with kd13

3O99 の概要

• エントリーDOI: 10.2210/pdb3o99/pdb
• 関連するPDBエントリー: 3O9A 3O9B 3O9C 3O9D 3O9E 3O9F 3O9G 3O9H 3O9I
• 分子名称: Pol polyprotein, PHOSPHATE ION, (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl [(1S,2R)-3-{[(4-aminophenyl)sulfonyl][(2S)-2-methylbutyl]amino}-1-benzyl-2-hydroxypropyl]carbamate, ... (5 entities in total)
• 機能のキーワード: hiv-1 protease, drug resistance, drug design, protease inhibitors, aids, aspartyl protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus 1 (HIV-1)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22442.26

構造登録者

Schiffer, C.A.,Nalam, M.N.L. (登録日: 2010-08-04, 公開日: 2011-08-10, 最終更新日: 2023-09-06)

• 主引用文献: Nalam, M.N.,Ali, A.,Reddy, G.S.,Cao, H.,Anjum, S.G.,Altman, M.D.,Yilmaz, N.K.,Tidor, B.,Rana, T.M.,Schiffer, C.A.; Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance.; Chem.Biol., 20:1116-1124, 2013; PubMed: 24012370; DOI: 10.1016/j.chembiol.2013.07.014

実験手法

X-RAY DIFFRACTION (1.95 Å)