3O2M

Crystal Structure of JNK1-alpha1 isoform complex with a biaryl tetrazol (A-82118)

3O2M の概要

関連するPDBエントリー3O17
分子名称Mitogen-activated protein kinase 8, C-Jun-amino-terminal kinase-interacting protein 1, JIP1, 10MER PEPTIDE, N-butyl-4,6-dimethyl-N-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}pyrimidin-2-amine, ... (4 entities in total)
機能のキーワードserine threonine protein kinase, atp binding, phosphorylation, kinase-inhibitor complex, transferase-inhibitor complex, transferase/inhibitor
由来する生物種Homo sapiens (human)
詳細
細胞内の位置Cytoplasm (By similarity) Q9WVI9
ポリマー鎖数4
分子量合計89337.17
構造登録者
Abad-Zapatero, C. (登録日: 2010-07-22, 公開日: 2011-01-12, 最終更新日: 2011-09-14)
主引用文献
Comess, K.M.,Sun, C.,Abad-Zapatero, C.,Goedken, E.R.,Gum, R.J.,Borhani, D.W.,Argiriadi, M.,Groebe, D.R.,Jia, Y.,Clampit, J.E.,Haasch, D.L.,Smith, H.T.,Wang, S.,Song, D.,Coen, M.L.,Cloutier, T.E.,Tang, H.,Cheng, X.,Quinn, C.,Liu, B.,Xin, Z.,Liu, G.,Fry, E.H.,Stoll, V.,Ng, T.I.,Banach, D.,Marcotte, D.,Burns, D.J.,Calderwood, D.J.,Hajduk, P.J.
Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.
Acs Chem.Biol., 6:234-244, 2011
PubMed: 21090814 (主引用文献が同じPDBエントリー)
DOI: 10.1021/cb1002619
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.7 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.270213.3%10.4%3.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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