3NY8

Crystal structure of the human beta2 adrenergic receptor in complex with the inverse agonist ICI 118,551

3NY8 の概要

• エントリーDOI: 10.2210/pdb3ny8/pdb
• 関連するPDBエントリー: 2RH1 3D4S 3NY9 3NYA
• 分子名称: Beta-2 adrenergic receptor, Lysozyme, CHOLESTEROL, (2S,3S)-1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]butan-2-ol, ... (7 entities in total)
• 機能のキーワード: g protein-coupled receptor, lysozyme, fusion, transducer, adrenergic, g-proteins, arrestins, adrenalin, ici 118, 551, glycosylation, palmitoylation, phosphorylation, membrane protein, hydrolase, structural genomics, psi-2, protein structure initiative, accelerated technologies center for gene to 3d structure, atcg3d, gpcr network, gpcr
• 由来する生物種: Homo sapiens; 詳細
• 細胞内の位置: Cell membrane ; Multi- pass membrane protein : P07550
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 58154.35

構造登録者

Wacker, D.,Fenalti, G.,Brown, M.A.,Katritch, V.,Abagyan, R.,Cherezov, V.,Stevens, R.C.,Accelerated Technologies Center for Gene to 3D Structure (ATCG3D),GPCR Network (GPCR) (登録日: 2010-07-14, 公開日: 2010-08-11, 最終更新日: 2023-09-06)

• 主引用文献: Wacker, D.,Fenalti, G.,Brown, M.A.,Katritch, V.,Abagyan, R.,Cherezov, V.,Stevens, R.C.; Conserved Binding Mode of Human beta(2) Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography; J.Am.Chem.Soc., 132:11443-11445, 2010; PubMed: 20669948; DOI: 10.1021/ja105108q

実験手法

X-RAY DIFFRACTION (2.84 Å)