3NXY
Preferential Selection of Isomer Binding from Chiral Mixtures: Alernate Binding Modes Observed fro the E- and Z-isomers of a Series of 5-Substituted 2,4-Diaminofuro[2,3-d]pyrimidines as Ternary Complexes with NADPH and Human Dihydrofolate Reductase
3NXY の概要
エントリーDOI | 10.2210/pdb3nxy/pdb |
関連するPDBエントリー | 3d7x 3d7y 3gyf 3NXO 3NXR 3NXT 3NXV 3NXX 3NXY 3NZ6 3NZ9 3NZA 3NZB 3NZC 3NZD |
分子名称 | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(1E,3R)-2-(2-methoxyphenyl)-3-methylpent-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine, ... (5 entities in total) |
機能のキーワード | chiral mixtures preferential binding, oxidoreductase |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Mitochondrion : P00374 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 22625.48 |
構造登録者 | |
主引用文献 | Cody, V.,Piraino, J.,Pace, J.,Li, W.,Gangjee, A. Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase. Acta Crystallogr.,Sect.D, 66:1271-1277, 2010 Cited by PubMed: 21123866DOI: 10.1107/S0907444910035808 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.9 Å) |
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