3NXT

Preferential Selection of Isomer Binding from Chiral Mixtures: Alternate Binding Modes Observed for the E-and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2m,3-d]pyrimidines as Ternary Complexes with NADPH and Human Dihydrofolate Reductase

3NXT の概要

• エントリーDOI: 10.2210/pdb3nxt/pdb
• 関連するPDBエントリー: 3d7x 3d7y 3gyf 3NXO 3NXR 3NXV 3NXX 3NXY 3NZ6 3NZ9 3NZA 3NZB 3NZC 3NZD
• 分子名称: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 5-[(E)-2-cyclopropyl-2-(2-methoxyphenyl)ethenyl]furo[2,3-d]pyrimidine-2,4-diamine, ... (5 entities in total)
• 機能のキーワード: chiral selectivity e-z-isomers, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22801.56

構造登録者

Cody, V. (登録日: 2010-07-14, 公開日: 2010-12-01, 最終更新日: 2024-04-03)

• 主引用文献: Cody, V.,Piraino, J.,Pace, J.,Li, W.,Gangjee, A.; Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase.; Acta Crystallogr.,Sect.D, 66:1271-1277, 2010; PubMed: 21123866; DOI: 10.1107/S0907444910035808

実験手法

X-RAY DIFFRACTION (1.7 Å)