3NUG

Crystal structure of wild type tetrameric pyridoxal 4-dehydrogenase from Mesorhizobium loti

3NUG の概要

• エントリーDOI: 10.2210/pdb3nug/pdb
• 分子名称: 3-oxoacyl-(Acyl-carrier protein) reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ACETIC ACID, ... (4 entities in total)
• 機能のキーワード: pyridoxal, tpldh, 4-pyridoxolactone, short chain dehydrogenase/reductase, oxidoreductase
• 由来する生物種: Mesorhizobium loti
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 104421.41

構造登録者

Chu, H.N. (登録日: 2010-07-06, 公開日: 2011-04-20, 最終更新日: 2023-11-01)

主引用文献

Chu, H.N.,Kobayashi, J.,Mikami, B.,Yagi, T.
The crystal structure of SDR-type pyridoxal 4-dehydrogenase of Mesorhizobium loti
Biosci.Biotechnol.Biochem., 75:388-390, 2011

PubMed Abstract: Pyridoxal 4-dehydrogenase catalyzes the irreversible oxidation of pyridoxal to 4-pyridoxolactone and is involved in degradation pathway I of pyridoxine, a vitamin B(6) compound. Its crystal structure was elucidated for the first time. Molecular replacement with (S)-1-phenylthanol dehydrogenase (PDB code 2EW8) was adopted to determine the tertiary structure of the NAD(+)-bound enzyme.

PubMed: 21307574
DOI: 10.1271/bbb.100748

実験手法

X-RAY DIFFRACTION (1.788 Å)