3NTK

Crystal structure of Tudor

3NTK の概要

• エントリーDOI: 10.2210/pdb3ntk/pdb
• 関連するPDBエントリー: 3NTH 3NTI
• 分子名称: Maternal protein tudor (2 entities in total)
• 機能のキーワード: tudor domain, ob-fold, germ cell formation, transcription
• 由来する生物種: Drosophila melanogaster (Fruit fly)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 38395.23

構造登録者

Liu, H.P.,Huang, Y.,Li, Z.Z.,Gong, W.M.,Xu, R.M. (登録日: 2010-07-05, 公開日: 2010-09-15, 最終更新日: 2024-11-20)

主引用文献

Liu, H.P.,Wang, J.Y.,Huang, Y.,Li, Z.Z.,Gong, W.M.,Lehmann, R.,Xu, R.M.
Structural basis for methylarginine-dependent recognition of Aubergine by Tudor
Genes Dev., 24:1876-1881, 2010

PubMed Abstract: Piwi proteins are modified by symmetric dimethylation of arginine (sDMA), and the methylarginine-dependent interaction with Tudor domain proteins is critical for their functions in germline development. Cocrystal structures of an extended Tudor domain (eTud) of Drosophila Tudor with methylated peptides of Aubergine, a Piwi family protein, reveal that sDMA is recognized by an asparagine-gated aromatic cage. Furthermore, the unexpected Tudor-SN/p100 fold of eTud is important for sensing the position of sDMA. The structural information provides mechanistic insights into sDMA-dependent Piwi-Tudor interaction, and the recognition of sDMA by Tudor domains in general.

PubMed: 20713507
DOI: 10.1101/gad.1956010

実験手法

X-RAY DIFFRACTION (1.8 Å)