3NSQ

Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron

Related	3NSP
Descriptor	Retinoid X receptor, alpha, 1,8-dihydroxyanthracene-9,10-dione (3 entities in total)
Functional Keywords	nuclear receptor retinoic x recepor alpha ligand binding domain antagonist danthron, transcription
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total molecular weight	53952.29
Authors	Zhang, H.,Hu, T.,Li, L.,Zhou, R.,Chen, L.,Hu, L.,Jiang, H.,Shen, X. (deposition date: 2010-07-02, release date: 2010-11-17, Last modification date: 2012-04-11)
Primary citation	Zhang, H.,Zhou, R.,Li, L.,Chen, J.,Chen, L.,Li, C.,Ding, H.,Yu, L.,Hu, L.,Jiang, H.,Shen, X. Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor. J.Biol.Chem., 286:1868-1875, 2011 PubMed: 21084305 (PDB entries with the same primary citation) DOI: 10.1074/jbc.M110.166215 Import into Mendeley
Experimental method	X-RAY DIFFRACTION (2.6 Å)
NMR Information	BMRB:15219 BMRB:6429 BMRB:6449