3NSQ

Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron

Summary for 3NSQ

Related3NSP
DescriptorRetinoid X receptor, alpha, 1,8-dihydroxyanthracene-9,10-dione (3 entities in total)
Functional Keywordsnuclear receptor retinoic x recepor alpha ligand binding domain antagonist danthron, transcription
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total molecular weight53952.29
Authors
Zhang, H.,Hu, T.,Li, L.,Zhou, R.,Chen, L.,Hu, L.,Jiang, H.,Shen, X. (deposition date: 2010-07-02, release date: 2010-11-17, Last modification date: 2012-04-11)
Primary citation
Zhang, H.,Zhou, R.,Li, L.,Chen, J.,Chen, L.,Li, C.,Ding, H.,Yu, L.,Hu, L.,Jiang, H.,Shen, X.
Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
J.Biol.Chem., 286:1868-1875, 2011
PubMed: 21084305 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M110.166215
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers26016.9%2.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3nsq
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Molmil generated image of 3nsq
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Molmil generated image of 3nsq
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More Biological unit images

Molmil generated image of 3nsq
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Molmil generated image of 3nsq
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Molmil generated image of 3nsq
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3nsq.pdb1.gz [127.58 KB])