3NRR
Co-crystal structure of dihydrofolate reductase-thymidylate synthase from Babesia bovis with dUMP, Raltitrexed and NADP
Summary for 3NRR
Entry DOI | 10.2210/pdb3nrr/pdb |
Related | 3i3r 3k2h |
Descriptor | Dihydrofolate reductase-thymidylate synthase, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (9 entities in total) |
Functional Keywords | structural genomics, seattle structural genomics center for infectious disease, ssgcid, niaid, dihydrofolate reductase, thymidylate synthase, dhfr, ts, thya, oxidoreductase, methyltransferase, babesiosis, dump, nadp, raltitrexed, tomudex, transferase |
Biological source | Babesia bovis |
Total number of polymer chains | 2 |
Total formula weight | 122165.90 |
Authors | Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2010-06-30, release date: 2010-07-14, Last modification date: 2023-09-06) |
Primary citation | Begley, D.W.,Edwards, T.E.,Raymond, A.C.,Smith, E.R.,Hartley, R.C.,Abendroth, J.,Sankaran, B.,Lorimer, D.D.,Myler, P.J.,Staker, B.L.,Stewart, L.J. Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis. Acta Crystallogr.,Sect.F, 67:1070-1077, 2011 Cited by PubMed: 21904052DOI: 10.1107/S1744309111029009 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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