3NRR

Co-crystal structure of dihydrofolate reductase-thymidylate synthase from Babesia bovis with dUMP, Raltitrexed and NADP

3NRR の概要

• エントリーDOI: 10.2210/pdb3nrr/pdb
• 関連するPDBエントリー: 3i3r 3k2h
• 分子名称: Dihydrofolate reductase-thymidylate synthase, CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (9 entities in total)
• 機能のキーワード: structural genomics, seattle structural genomics center for infectious disease, ssgcid, niaid, dihydrofolate reductase, thymidylate synthase, dhfr, ts, thya, oxidoreductase, methyltransferase, babesiosis, dump, nadp, raltitrexed, tomudex, transferase
• 由来する生物種: Babesia bovis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 122165.90

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2010-06-30, 公開日: 2010-07-14, 最終更新日: 2023-09-06)

• 主引用文献: Begley, D.W.,Edwards, T.E.,Raymond, A.C.,Smith, E.R.,Hartley, R.C.,Abendroth, J.,Sankaran, B.,Lorimer, D.D.,Myler, P.J.,Staker, B.L.,Stewart, L.J.; Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis.; Acta Crystallogr.,Sect.F, 67:1070-1077, 2011; PubMed: 21904052; DOI: 10.1107/S1744309111029009

実験手法

X-RAY DIFFRACTION (1.8 Å)