3NRM
Imidazo[1,2-a]pyrazine-based Aurora Kinase Inhibitors
Summary for 3NRM
Entry DOI | 10.2210/pdb3nrm/pdb |
Descriptor | Serine/threonine-protein kinase 6, N-(3-methylisothiazol-5-yl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amine (2 entities in total) |
Functional Keywords | kinase, cell cycle, inhibitor, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, centrosome: O14965 |
Total number of polymer chains | 1 |
Total formula weight | 32855.65 |
Authors | Hruza, A. (deposition date: 2010-06-30, release date: 2010-08-18, Last modification date: 2023-09-06) |
Primary citation | Belanger, D.B.,Curran, P.J.,Hruza, A.,Voigt, J.,Meng, Z.,Mandal, A.K.,Siddiqui, M.A.,Basso, A.D.,Gray, K. Discovery of imidazo[1,2-a]pyrazine-based Aurora kinase inhibitors. Bioorg.Med.Chem.Lett., 20:5170-5174, 2010 Cited by PubMed: 20674350DOI: 10.1016/j.bmcl.2010.07.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.05 Å) |
Structure validation
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