3NR9
Structure of human CDC2-like kinase 2 (CLK2)
Summary for 3NR9
Entry DOI | 10.2210/pdb3nr9/pdb |
Descriptor | Dual specificity protein kinase CLK2, (5Z)-5-(quinolin-6-ylmethylidene)-2-[(thiophen-2-ylmethyl)amino]-1,3-thiazol-4(5H)-one (3 entities in total) |
Functional Keywords | structural genomics consortium, sgc, protein kinase, dual specificity protein kinase, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Nucleus. Isoform 2: Nucleus speckle: P49760 |
Total number of polymer chains | 3 |
Total formula weight | 131218.88 |
Authors | Chaikuad, A.,Savitsky, P.,Krojer, T.,Muniz, J.R.C.,Filippakopoulos, P.,Rellos, P.,Keates, T.,Fedorov, O.,Pike, A.C.W.,Eswaran, J.,Berridge, G.,Phillips, C.,Zhang, Y.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2010-06-30, release date: 2010-08-25, Last modification date: 2023-09-06) |
Primary citation | Chaikuad, A.,Savitsky, P.,Krojer, T.,Muniz, J.R.C.,Filippakopoulos, P.,Rellos, P.,Keates, T.,Fedorov, O.,Pike, A.C.W.,Eswaran, J.,Berridge, G.,Phillips, C.,Zhang, Y.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) Structure of human CDC2-like kinase 2 (CLK2) To be Published, |
Experimental method | X-RAY DIFFRACTION (2.89 Å) |
Structure validation
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