3NR8

Crystal structure of human SHIP2

Summary for 3NR8

• Entry DOI: 10.2210/pdb3nr8/pdb
• Related: 3MTC 3N9V
• Descriptor: Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2, CHLORIDE ION (3 entities in total)
• Functional Keywords: structural genomics consortium, sgc, phosphatidylinositol-3, 4, 5-trisphosphate 5-phosphatase 2, ship2, inppl1, ship-2, phosphatidylinositol, phosphatase, signalling, magnesium, structural genomics consortium stockholm, magnesium binding, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytosol: O15357
• Total number of polymer chains: 2
• Total formula weight: 72523.16

Authors

Tresaugues, L.,Welin, M.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Karlberg, T.,Kol, S.,Kotenyova, T.,Kouznetsova, E.,Moche, M.,Nyman, T.,Persson, C.,Schuler, H.,Schutz, P.,Siponen, M.I.,Thorsell, A.G.,van der Berg, S.,Wahlberg, E.,Weigelt, J.,Nordlund, P.,Structural Genomics Consortium (SGC) (deposition date: 2010-06-30, release date: 2010-08-25, Last modification date: 2023-09-06)

• Primary citation: Tresaugues, L.,Silvander, C.,Flodin, S.,Welin, M.,Nyman, T.,Graslund, S.,Hammarstrom, M.,Berglund, H.,Nordlund, P.; Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases; Structure, 22:744-755, 2014; PubMed: 24704254; DOI: 10.1016/j.str.2014.01.013

Experimental method

X-RAY DIFFRACTION (2.8 Å)