3NR8
Crystal structure of human SHIP2
Summary for 3NR8
Entry DOI | 10.2210/pdb3nr8/pdb |
Related | 3MTC 3N9V |
Descriptor | Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2, CHLORIDE ION (3 entities in total) |
Functional Keywords | structural genomics consortium, sgc, phosphatidylinositol-3, 4, 5-trisphosphate 5-phosphatase 2, ship2, inppl1, ship-2, phosphatidylinositol, phosphatase, signalling, magnesium, structural genomics consortium stockholm, magnesium binding, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytosol: O15357 |
Total number of polymer chains | 2 |
Total formula weight | 72523.16 |
Authors | Tresaugues, L.,Welin, M.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Karlberg, T.,Kol, S.,Kotenyova, T.,Kouznetsova, E.,Moche, M.,Nyman, T.,Persson, C.,Schuler, H.,Schutz, P.,Siponen, M.I.,Thorsell, A.G.,van der Berg, S.,Wahlberg, E.,Weigelt, J.,Nordlund, P.,Structural Genomics Consortium (SGC) (deposition date: 2010-06-30, release date: 2010-08-25, Last modification date: 2023-09-06) |
Primary citation | Tresaugues, L.,Silvander, C.,Flodin, S.,Welin, M.,Nyman, T.,Graslund, S.,Hammarstrom, M.,Berglund, H.,Nordlund, P. Structural basis for phosphoinositide substrate recognition, catalysis, and membrane interactions in human inositol polyphosphate 5-phosphatases Structure, 22:744-755, 2014 Cited by PubMed: 24704254DOI: 10.1016/j.str.2014.01.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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