3NR1

A metazoan ortholog of SpoT hydrolyzes ppGpp and plays a role in starvation responses

Summary for 3NR1

Entry DOI	10.2210/pdb3nr1/pdb
Descriptor	HD domain-containing protein 3, MANGANESE (II) ION (3 entities in total)
Functional Keywords	stringent response, pyrophosphohydrolase, hd (histidine and aspartic acid) family, ppgpp hydrolase, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	40571.57
Authors	Sun, D.W.,Kim, H.Y.,Kim, K.J.,Jeon, Y.H.,Chung, J. (deposition date: 2010-06-30, release date: 2010-09-08, Last modification date: 2023-12-27)
Primary citation	Sun, D.W.,Lee, G.,Lee, J.H.,Kim, H.Y.,Rhee, H.W.,Park, S.Y.,Kim, K.J.,Kim, Y.,Kim, B.Y.,Hong, J.I.,Park, C.,Choy, H.E.,Kim, J.H.,Jeon, Y.H.,Chung, J. A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses Nat.Struct.Mol.Biol., 17:1188-1194, 2010 Cited by PubMed: 20818390 DOI: 10.1038/nsmb.1906 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation