3NPC
Crystal structure of JNK2 complexed with BIRB796
3NPC の概要
エントリーDOI | 10.2210/pdb3npc/pdb |
分子名称 | Mitogen-activated protein kinase 9, 1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA (3 entities in total) |
機能のキーワード | dfg-out, protein kinase, transferase, atp binding, type ii kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 84847.97 |
構造登録者 | |
主引用文献 | Kuglstatter, A.,Ghate, M.,Tsing, S.,Villasenor, A.G.,Shaw, D.,Barnett, J.W.,Browner, M.F. X-ray crystal structure of JNK2 complexed with the p38alpha inhibitor BIRB796: Insights into the rational design of DFG-out binding MAP kinase inhibitors. Bioorg.Med.Chem.Lett., 20:5217-5220, 2010 Cited by PubMed: 20655210DOI: 10.1016/j.bmcl.2010.06.157 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.35 Å) |
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