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3NP7

Glycogen phosphorylase complexed with 2,5-dihydroxy-3-(beta-D-glucopyranosyl)-chlorobenzene and 2,5-dihydroxy-4-(beta-D-glucopyranosyl)-chlorobenzene

Summary for 3NP7
Entry DOI10.2210/pdb3np7/pdb
Related3NP9 3NPA
DescriptorGlycogen phosphorylase, muscle form, (1S)-1,5-anhydro-1-(4-chloro-2,5-dihydroxyphenyl)-D-glucitol, (1S)-1,5-anhydro-1-(3-chloro-2,5-dihydroxyphenyl)-D-glucitol, ... (4 entities in total)
Functional Keywordsglycogenolysis, type 2 diabetes, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceOryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
Total number of polymer chains1
Total formula weight98439.41
Authors
Alexacou, K.-M. (deposition date: 2010-06-28, release date: 2011-06-08, Last modification date: 2023-11-22)
Primary citationAlexacou, K.M.,Zhang, Y.Z.,Praly, J.P.,Zographos, S.E.,Chrysina, E.D.,Oikonomakos, N.G.,Leonidas, D.D.
Halogen-substituted (C-beta-D-glucopyranosyl)-hydroquinone regioisomers: synthesis, enzymatic evaluation and their binding to glycogen phosphorylase.
Bioorg.Med.Chem., 19:5125-5136, 2011
Cited by
PubMed: 21821421
DOI: 10.1016/j.bmc.2011.07.024
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.05 Å)
Structure validation

217705

數據於2024-03-27公開中

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