3NP7

Glycogen phosphorylase complexed with 2,5-dihydroxy-3-(beta-D-glucopyranosyl)-chlorobenzene and 2,5-dihydroxy-4-(beta-D-glucopyranosyl)-chlorobenzene

3NP7 の概要

• エントリーDOI: 10.2210/pdb3np7/pdb
• 関連するPDBエントリー: 3NP9 3NPA
• 分子名称: Glycogen phosphorylase, muscle form, (1S)-1,5-anhydro-1-(4-chloro-2,5-dihydroxyphenyl)-D-glucitol, (1S)-1,5-anhydro-1-(3-chloro-2,5-dihydroxyphenyl)-D-glucitol, ... (4 entities in total)
• 機能のキーワード: glycogenolysis, type 2 diabetes, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 98439.41

構造登録者

Alexacou, K.-M. (登録日: 2010-06-28, 公開日: 2011-06-08, 最終更新日: 2023-11-22)

• 主引用文献: Alexacou, K.M.,Zhang, Y.Z.,Praly, J.P.,Zographos, S.E.,Chrysina, E.D.,Oikonomakos, N.G.,Leonidas, D.D.; Halogen-substituted (C-beta-D-glucopyranosyl)-hydroquinone regioisomers: synthesis, enzymatic evaluation and their binding to glycogen phosphorylase.; Bioorg.Med.Chem., 19:5125-5136, 2011; PubMed: 21821421; DOI: 10.1016/j.bmc.2011.07.024

実験手法

X-RAY DIFFRACTION (2.05 Å)