3NOA
Crystal structure of human PPAR-gamma ligand binding domain complex with a potency improved agonist
Summary for 3NOA
Entry DOI | 10.2210/pdb3noa/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, (5-{3-[4-(biphenyl-4-ylcarbonyl)-2-propylphenoxy]propoxy}-1H-indol-1-yl)acetic acid (3 entities in total) |
Functional Keywords | hypoglycemic agents, models, molecular, ppar alpha, ppar gamma, protein isoforms, quinolines, structure-activity relationship, thiazolidinediones, transcription |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P37231 |
Total number of polymer chains | 2 |
Total formula weight | 63089.32 |
Authors | Peng, Y.H.,Wu, J.S.,Wu, S.Y. (deposition date: 2010-06-25, release date: 2011-06-29, Last modification date: 2023-11-01) |
Primary citation | Peng, Y.H.,Coumar, M.S.,Leou, J.S.,Wu, J.S.,Shiao, H.Y.,Lin, C.H.,Lyu, P.C.,Hsieh, H.P.,Wu, S.Y. Crystal structure of human PPAR-gamma ligand binding domain complex with a potency improved agonist To be published, |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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