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3NNY

Structure of rat neuronal nitric oxide synthase heme domain complexed with 6-(((3R,4R)-4-(2-(3-Fluorophenethylamino)ethoxy)pyrrolidin-3-yl)methyl)pyridin-2-amine

Summary for 3NNY
Entry DOI10.2210/pdb3nny/pdb
Related3NLD 3NLE 3NLF 3NLG 3NLH 3NLI 3NLJ 3NLK 3NLM 3NLN 3NLO 3NLP 3NLQ 3NLR 3NLT 3NLU 3NLV 3NLW 3NLX 3NLY 3NLZ 3NM0 3NNZ
DescriptorNitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywordsnitric oxide synthase, heme enzyme, inhibitor, oxidoreductase
Biological sourceRattus norvegicus (brown rat,rat,rats)
Total number of polymer chains2
Total formula weight100240.93
Authors
Li, H.,Poulos, T.L. (deposition date: 2010-06-24, release date: 2010-10-06, Last modification date: 2023-09-06)
Primary citationXue, F.,Li, H.,Fang, J.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.
Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase.
Bioorg.Med.Chem.Lett., 20:6258-6261, 2010
Cited by
PubMed: 20833542
DOI: 10.1016/j.bmcl.2010.08.096
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

數據於2024-03-27公開中

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