3NNY

Structure of rat neuronal nitric oxide synthase heme domain complexed with 6-(((3R,4R)-4-(2-(3-Fluorophenethylamino)ethoxy)pyrrolidin-3-yl)methyl)pyridin-2-amine

3NNY の概要

• エントリーDOI: 10.2210/pdb3nny/pdb
• 関連するPDBエントリー: 3NLD 3NLE 3NLF 3NLG 3NLH 3NLI 3NLJ 3NLK 3NLM 3NLN 3NLO 3NLP 3NLQ 3NLR 3NLT 3NLU 3NLV 3NLW 3NLX 3NLY 3NLZ 3NM0 3NNZ
• 分子名称: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: nitric oxide synthase, heme enzyme, inhibitor, oxidoreductase
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100240.93

構造登録者

Li, H.,Poulos, T.L. (登録日: 2010-06-24, 公開日: 2010-10-06, 最終更新日: 2023-09-06)

• 主引用文献: Xue, F.,Li, H.,Fang, J.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.; Peripheral but crucial: a hydrophobic pocket (Tyr(706), Leu(337), and Met(336)) for potent and selective inhibition of neuronal nitric oxide synthase.; Bioorg.Med.Chem.Lett., 20:6258-6261, 2010; PubMed: 20833542; DOI: 10.1016/j.bmcl.2010.08.096

実験手法

X-RAY DIFFRACTION (2.1 Å)