3NM0

Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(((3R,4R)-4-(2-(2,2-Difluoro-2-phenylethylamino)ethoxy) pyrrolidin-3-yl)methyl)-4-methyl-3,4,5,6-tetrahydropyridin-2-amine

Summary for 3NM0

Entry DOI	10.2210/pdb3nm0/pdb
Related	3NLD 3NLE 3NLF 3NLG 3NLH 3NLI 3NLJ 3NLK 3NLM 3NLN 3NLO 3NLP 3NLQ 3NLR 3NLT 3NLU 3NLV 3NLW 3NLX 3NLY 3NLZ
Descriptor	Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
Functional Keywords	nitric oxide synthase, heme thiolate enzyme inhibitor, oxidoreductase
Biological source	Rattus norvegicus (brown rat,rat,rats)
Cellular location	Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
Total number of polymer chains	2
Total formula weight	100313.02
Authors	Li, H.,Delker, S.L.,Poulos, T.L. (deposition date: 2010-06-21, release date: 2011-01-19, Last modification date: 2023-09-06)
Primary citation	Xue, F.,Li, H.,Delker, S.L.,Fang, J.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Potent, highly selective, and orally bioavailable gem-difluorinated monocationic inhibitors of neuronal nitric oxide synthase. J.Am.Chem.Soc., 132:14229-14238, 2010 Cited by PubMed: 20843082 DOI: 10.1021/ja106175q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.81 Å)

Structure validation