3NLZ

Structure of rat neuronal nitric oxide synthase heme domain in complex with 6-(((3R,4R)-4-(2-(2,2-Difluoro-2-phenylethylamino)ethoxy)pyrrolidin-3-yl)methyl)-4-methylpyridin-2-amine

3NLZ の概要

• エントリーDOI: 10.2210/pdb3nlz/pdb
• 関連するPDBエントリー: 3NLD 3NLE 3NLF 3NLG 3NLH 3NLI 3NLJ 3NLK 3NLM 3NLN 3NLO 3NLP 3NLQ 3NLR 3NLT 3NLU 3NLV 3NLW 3NLX 3NLY 3NM0 3NNY 3NNZ
• 分子名称: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total)
• 機能のキーワード: nitric oxide synthase, heme thiolate enzyme, inhibitor, oxidoreductase
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• 細胞内の位置: Cell membrane, sarcolemma ; Peripheral membrane protein : P29476
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100397.05

構造登録者

Li, H.,Delker, S.L.,Poulos, T.L. (登録日: 2010-06-21, 公開日: 2011-01-19, 最終更新日: 2023-09-06)

• 主引用文献: Xue, F.,Li, H.,Delker, S.L.,Fang, J.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.; Potent, highly selective, and orally bioavailable gem-difluorinated monocationic inhibitors of neuronal nitric oxide synthase.; J.Am.Chem.Soc., 132:14229-14238, 2010; PubMed: 20843082; DOI: 10.1021/ja106175q

実験手法

X-RAY DIFFRACTION (1.92 Å)