3NLU

Structure of endothelial nitric oxide synthase heme domain complexed with N1-{(3'R,4'R)-4'-[(6"-amino-4"-methylpyridin-2"-yl)methyl]pyrrolidin-3'-yl}-N2-(3'-fluorophenethyl)ethane-1,2-diamine tetrahydrochloride

3NLU の概要

• エントリーDOI: 10.2210/pdb3nlu/pdb
• 関連するPDBエントリー: 3NLD 3NLE 3NLF 3NLG 3NLH 3NLI 3NLJ 3NLK 3NLM 3NLN 3NLO 3NLP 3NLQ 3NLR 3NLT 3NLV 3NLW 3NLX 3NLY 3NLZ 3NM0 3NNY 3NNZ
• 分子名称: Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (9 entities in total)
• 機能のキーワード: nitric oxide synthase, heme enzyme, substrate inhibitor, oxidoreductase
• 由来する生物種: Bos taurus (bovine,cow,domestic cattle,domestic cow)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 102537.23

構造登録者

Xue, F.,Li, H.,Fang, J.,Delker, S.L.,Poulos, T.L.,Silverman, R.B. (登録日: 2010-06-21, 公開日: 2011-01-19, 最終更新日: 2024-02-21)

• 主引用文献: Xue, F.,Li, H.,Delker, S.L.,Fang, J.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.; Potent, highly selective, and orally bioavailable gem-difluorinated monocationic inhibitors of neuronal nitric oxide synthase.; J.Am.Chem.Soc., 132:14229-14238, 2010; PubMed: 20843082; DOI: 10.1021/ja106175q

実験手法

X-RAY DIFFRACTION (2.65 Å)