3NLN
Structure of neuronal nitric oxide synthase R349A mutant heme domain in complex with 6-{{(3'R,4'S)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine
3NLN の概要
エントリーDOI | 10.2210/pdb3nln/pdb |
関連するPDBエントリー | 3NLD 3NLE 3NLF 3NLG 3NLH 3NLI 3NLJ 3NLK 3NLM 3NLO 3NLP 3NLQ 3NLR 3NLT 3NLU 3NLV 3NLW 3NLX 3NLY 3NLZ 3NM0 |
分子名称 | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
機能のキーワード | nitric oxide synthase, inhibitor, heme enzyme, oxidoreductase |
由来する生物種 | Rattus norvegicus (brown rat,rat,rats) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 100096.75 |
構造登録者 | |
主引用文献 | Ji, H.,Delker, S.L.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives. J.Med.Chem., 53:7804-7824, 2010 Cited by PubMed: 20958055DOI: 10.1021/jm100947x 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
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