3NLM

Structure of neuronal nitric oxide synthase heme domain in complex with 6-{{(3'R,4'R)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine

3NLM の概要

• エントリーDOI: 10.2210/pdb3nlm/pdb
• 関連するPDBエントリー: 3NLD 3NLE 3NLF 3NLG 3NLH 3NLI 3NLJ 3NLK 3NLN 3NLO 3NLP 3NLQ 3NLR 3NLT 3NLU 3NLV 3NLW 3NLX 3NLY 3NLZ 3NM0
• 分子名称: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 6-{[(3R,4R)-4-(2-{[2-(3-fluorophenyl)ethyl]amino}ethoxy)pyrrolidin-3-yl]methyl}-4-methylpyridin-2-amine, ... (7 entities in total)
• 機能のキーワード: nitric oxide synthase, inhibitor, heme enzyme, oxidoreductase
• 由来する生物種: Rattus norvegicus (brown rat,rat,rats)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100268.98

構造登録者

Li, H.,Delker, S.L.,Poulos, T.L. (登録日: 2010-06-21, 公開日: 2010-11-03, 最終更新日: 2023-09-06)

• 主引用文献: Ji, H.,Delker, S.L.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B.; Exploration of the Active Site of Neuronal Nitric Oxide Synthase by the Design and Synthesis of Pyrrolidinomethyl 2-Aminopyridine Derivatives.; J.Med.Chem., 53:7804-7824, 2010; PubMed: 20958055; DOI: 10.1021/jm100947x

実験手法

X-RAY DIFFRACTION (1.85 Å)