3NJ4

Fluoro-neplanocin A in Human S-Adenosylhomocysteine Hydrolase

Summary for 3NJ4

• Entry DOI: 10.2210/pdb3nj4/pdb
• Descriptor: Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (4S,5S)-4-(6-amino-9H-purin-9-yl)-3-fluoro-5-hydroxy-2-(hydroxymethyl)cyclopent-2-en-1-one, ... (4 entities in total)
• Functional Keywords: s-adenosylhomocystein, hydrolase, nad
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P23526
• Total number of polymer chains: 4
• Total formula weight: 195991.52

Authors

Jeong, L.S.,Lee, K.M.,Hwang, K.Y.,Choi, S.,Heo, Y.S. (deposition date: 2010-06-17, release date: 2011-05-04, Last modification date: 2024-03-20)

• Primary citation: Lee, K.M.,Choi, W.J.,Lee, Y.,Lee, H.J.,Zhao, L.X.,Lee, H.W.,Park, J.G.,Kim, H.O.,Hwang, K.Y.,Heo, Y.S.,Choi, S.,Jeong, L.S.; X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues.; J.Med.Chem., 54:930-938, 2011; PubMed: 21226494; DOI: 10.1021/jm1010836

Experimental method

X-RAY DIFFRACTION (2.5 Å)