3NJ4

Fluoro-neplanocin A in Human S-Adenosylhomocysteine Hydrolase

3NJ4 の概要

• エントリーDOI: 10.2210/pdb3nj4/pdb
• 分子名称: Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (4S,5S)-4-(6-amino-9H-purin-9-yl)-3-fluoro-5-hydroxy-2-(hydroxymethyl)cyclopent-2-en-1-one, ... (4 entities in total)
• 機能のキーワード: s-adenosylhomocystein, hydrolase, nad
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P23526
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 195991.52

構造登録者

Jeong, L.S.,Lee, K.M.,Hwang, K.Y.,Choi, S.,Heo, Y.S. (登録日: 2010-06-17, 公開日: 2011-05-04, 最終更新日: 2024-03-20)

• 主引用文献: Lee, K.M.,Choi, W.J.,Lee, Y.,Lee, H.J.,Zhao, L.X.,Lee, H.W.,Park, J.G.,Kim, H.O.,Hwang, K.Y.,Heo, Y.S.,Choi, S.,Jeong, L.S.; X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues.; J.Med.Chem., 54:930-938, 2011; PubMed: 21226494; DOI: 10.1021/jm1010836

実験手法

X-RAY DIFFRACTION (2.5 Å)