3NH7
Crystal structure of the neutralizing Fab fragment AbD1556 bound to the BMP type I receptor IA
Summary for 3NH7
Entry DOI | 10.2210/pdb3nh7/pdb |
Related | 1REW 2K3G |
Descriptor | Antibody fragment Fab AbD1556, heavy chain, Antibody fragment Fab AbD1556, light chain, Bone morphogenetic protein receptor type-1A, ... (4 entities in total) |
Functional Keywords | antibody-antigen complex, bmp receptor extracellular domain, bone morphogenetic protein, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P36894 |
Total number of polymer chains | 12 |
Total formula weight | 247366.70 |
Authors | Mueller, T.D.,Harth, S.,Sebald, W. (deposition date: 2010-06-14, release date: 2010-10-27, Last modification date: 2024-10-30) |
Primary citation | Harth, S.,Kotzsch, A.,Hu, J.,Sebald, W.,Mueller, T.D. A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity Plos One, 5:e13049-e13049, 2010 Cited by PubMed Abstract: Members of the TGF-β superfamily are characterized by a highly promiscuous ligand-receptor interaction as is readily apparent from the numeral discrepancy of only seven type I and five type II receptors available for more than 40 ligands. Structural and functional studies have been used to address the question of how specific signals can be deduced from a limited number of receptor combinations and to unravel the molecular mechanisms underlying the protein-protein recognition that allow such limited specificity. PubMed: 20927405DOI: 10.1371/journal.pone.0013049 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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