3NH7

Crystal structure of the neutralizing Fab fragment AbD1556 bound to the BMP type I receptor IA

3NH7 の概要

• エントリーDOI: 10.2210/pdb3nh7/pdb
• 関連するPDBエントリー: 1REW 2K3G
• 分子名称: Antibody fragment Fab AbD1556, heavy chain, Antibody fragment Fab AbD1556, light chain, Bone morphogenetic protein receptor type-1A, ... (4 entities in total)
• 機能のキーワード: antibody-antigen complex, bmp receptor extracellular domain, bone morphogenetic protein, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P36894
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 247366.70

構造登録者

Mueller, T.D.,Harth, S.,Sebald, W. (登録日: 2010-06-14, 公開日: 2010-10-27, 最終更新日: 2024-10-30)

主引用文献

Harth, S.,Kotzsch, A.,Hu, J.,Sebald, W.,Mueller, T.D.
A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity
Plos One, 5:e13049-e13049, 2010

PubMed Abstract: Members of the TGF-β superfamily are characterized by a highly promiscuous ligand-receptor interaction as is readily apparent from the numeral discrepancy of only seven type I and five type II receptors available for more than 40 ligands. Structural and functional studies have been used to address the question of how specific signals can be deduced from a limited number of receptor combinations and to unravel the molecular mechanisms underlying the protein-protein recognition that allow such limited specificity.

PubMed: 20927405
DOI: 10.1371/journal.pone.0013049

実験手法

X-RAY DIFFRACTION (2.7 Å)