3NG7

Complex of dithionite-reduced 6-hydroxy-L-nicotine oxidase with substrate bound at active site and inhibitor at exit cavity

3NG7 の概要

• エントリーDOI: 10.2210/pdb3ng7/pdb
• 関連するPDBエントリー: 3K7M 3K7Q 3K7T
• 分子名称: 6-hydroxy-L-nicotine oxidase, 5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-2-ol, FLAVIN-ADENINE DINUCLEOTIDE, ... (6 entities in total)
• 機能のキーワード: enantiomeric substrate-inhibitor, flavoenzymes, nicotine degradation, oxidase, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Arthrobacter nicotinovorans
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 49030.00

構造登録者

Kachalova, G.S.,Bartunik, H.D. (登録日: 2010-06-11, 公開日: 2011-03-16, 最終更新日: 2023-11-01)

• 主引用文献: Kachalova, G.,Decker, K.,Holt, A.,Bartunik, H.D.; Crystallographic snapshots of the complete reaction cycle of nicotine degradation by an amine oxidase of the monoamine oxidase (MAO) family; Proc.Natl.Acad.Sci.USA, 108:4800-4805, 2011; PubMed: 21383134; DOI: 10.1073/pnas.1016684108

実験手法

X-RAY DIFFRACTION (1.95 Å)