3NFP
Crystal structure of the Fab fragment of therapeutic antibody daclizumab in complex with IL-2Ra (CD25) ectodomain
Summary for 3NFP
Entry DOI | 10.2210/pdb3nfp/pdb |
Related | 3IU3 3NFS |
Descriptor | Heavy chain of Fab fragment of daclizumab, Light chain of Fab fragment of daclizumab, Interleukin-2 receptor subunit alpha, ... (4 entities in total) |
Functional Keywords | il-2ra, cd25, daclizumab, zenapax, therapeutic antibody, immune system, immune system-cytokine complex, immune system/cytokine |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: P01589 |
Total number of polymer chains | 6 |
Total formula weight | 143115.39 |
Authors | |
Primary citation | Yang, H.,Wang, J.,Du, J.,Zhong, C.,Zhang, D.,Guo, H.,Guo, Y.,Ding, J. Structural basis of immunosuppression by the therapeutic antibody daclizumab Cell Res., 20:1361-1371, 2010 Cited by PubMed: 20820193DOI: 10.1038/cr.2010.130 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.86 Å) |
Structure validation
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