3NFN

Recognition of peptide-MHC by a V-delta/V-beta TCR

「3NFJ」から置き換えられました

3NFN の概要

• エントリーDOI: 10.2210/pdb3nfn/pdb
• 関連するPDBエントリー: 3NFJ 3NFO
• 分子名称: HLA class I histocompatibility antigen, A-24 alpha chain, Beta-2-microglobulin, 10-mer peptide from Protein Nef, ... (4 entities in total)
• 機能のキーワード: immunoglobulin family, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P05534; Secreted: P61769
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44721.76

構造登録者

Shi, Y.,Qi, J.,Gao, F.,Gao, G.F. (登録日: 2010-06-10, 公開日: 2011-07-13, 最終更新日: 2024-10-30)

主引用文献

Shi, Y.,Qi, J.,Iwamoto, A.,Gao, G.F.
Plasticity of human CD8 alpha alpha binding to peptide-HLA-A*2402
Mol.Immunol., 48:2198-2202, 2011

PubMed Abstract: The human CD8 functions as a co-receptor for specific T cell recognition, and only one complex structure of human CD8αα binding to HLA-A*0201 has been solved, revealing the molecular basis of CD8 interacting with its ligand pHLA. Here, we present the complex structures of human CD8αα bound to HLA-A*2402, which demonstrate two opposite α3 domain CD loop shifts (either pull or push) in the HLA heavy chain upon CD8 engagement. Taking the previously reported mouse CD8-pMHC complex structures into account, from the structural view, all of the data indicate the plasticity of CD8 binding to pMHC/HLA, which facilitates its co-receptor function for T cells. The plasticity of CD8 binding appears not to affect the specificity of TCR recognition, as no peptide conformation change extends to the pMHC interface for TCR contacting.

PubMed: 21645925
DOI: 10.1016/j.molimm.2011.05.009

実験手法

X-RAY DIFFRACTION (2.392 Å)