3NDT

HIV-1 Protease Saquinavir:Ritonavir 1:1 complex structure

3NDT の概要

• エントリーDOI: 10.2210/pdb3ndt/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000454
• 分子名称: Protease, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1 -phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide, CHLORIDE ION, ... (6 entities in total)
• 機能のキーワード: hydrolase, aids, aspartyl protease, carbamylation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 BH10 (HIV-1)
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 45019.17

構造登録者

Geremia, S.,Olajuyigbe, F.M.,Demitri, N. (登録日: 2010-06-08, 公開日: 2011-07-20, 最終更新日: 2023-09-06)

• 主引用文献: Olajuyigbe, F.M.,Demitri, N.,Geremia, S.; Investigation of 2-Fold Disorder of Inhibitors and Relative Potency by Crystallizations of HIV-1 Protease in Ritonavir and Saquinavir Mixtures; Cryst.Growth Des., 11:4378-4385, 2011; DOI: 10.1021/cg200514z

実験手法

X-RAY DIFFRACTION (1.72 Å)