3NB5
Human carbonic anhydrase II in complex with 2-(3-chloro-4-hydroxyphenyl)-N-(4-sulfamoylphenethyl)acetamide
Summary for 3NB5
Entry DOI | 10.2210/pdb3nb5/pdb |
Descriptor | Carbonic anhydrase 2, ZINC ION, 2-(3-chloro-4-hydroxyphenyl)-N-[2-(4-sulfamoylphenyl)ethyl]acetamide, ... (5 entities in total) |
Functional Keywords | drug design, natural product, sulfamate, lyase-lyase inhibitor complex, lyase/lyase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00918 |
Total number of polymer chains | 1 |
Total formula weight | 29999.59 |
Authors | Hofmann, A.,Osman, A.,Davis, R.A. (deposition date: 2010-06-02, release date: 2011-04-20, Last modification date: 2023-11-01) |
Primary citation | Davis, R.A.,Hofmann, A.,Osman, A.,Hall, R.A.,Muhlschlegel, F.A.,Vullo, D.,Innocenti, A.,Supuran, C.T.,Poulsen, S.A. Natural Product-Based Phenols as Novel Probes for Mycobacterial and Fungal Carbonic Anhydrases J.Med.Chem., 54:1682-1692, 2011 Cited by PubMed: 21332115DOI: 10.1021/jm1013242 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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