3N9J

Structure of human Glutathione Transferase Pi class in complex with Ethacraplatin

Summary for 3N9J

• Entry DOI: 10.2210/pdb3n9j/pdb
• Descriptor: Glutathione S-transferase P, PLATINUM (II) ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (7 entities in total)
• Functional Keywords: transferase, glutathione, detoxification, ethacrynic acid, cisplatin, prodrug, ethacraplatin, platinum
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 48103.06

Authors

Parker, L.J.,Parker, M.W. (deposition date: 2010-05-30, release date: 2011-05-11, Last modification date: 2023-11-01)

• Primary citation: Parker, L.J.,Italiano, L.C.,Morton, C.J.,Hancock, N.C.,Ascher, D.B.,Aitken, J.B.,Harris, H.H.,Campomanes, P.,Rothlisberger, U.,De Luca, A.,Lo Bello, M.,Ang, W.H.,Dyson, P.J.,Parker, M.W.; Studies of glutathione transferase P1-1 bound to a platinum(IV)-based anticancer compound reveal the molecular basis of its activation.; To be Published,

Experimental method

X-RAY DIFFRACTION (1.85 Å)