3N7O
X-ray structure of human chymase in complex with small molecule inhibitor.
Summary for 3N7O
Entry DOI | 10.2210/pdb3n7o/pdb |
Descriptor | Chymase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (S)-[(1S)-1-(5-chloro-1-benzothiophen-3-yl)-2-{[(E)-2-(3,4-difluorophenyl)ethenyl]amino}-2-oxoethyl]methylphosphinic acid, ... (5 entities in total) |
Functional Keywords | serine protease, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 26300.47 |
Authors | Abad, M.C.,Kervinen, J.,Crysler, C.,Bayoumy, S.,Spurlino, J.,Deckman, I.,Greco, M.N.,Maryanoff, B.E.,Degaravilla, L. (deposition date: 2010-05-27, release date: 2010-07-21, Last modification date: 2023-09-06) |
Primary citation | Kervinen, J.,Crysler, C.,Bayoumy, S.,Abad, M.C.,Spurlino, J.,Deckman, I.,Greco, M.N.,Maryanoff, B.E.,de Garavilla, L. Potency variation of small-molecule chymase inhibitors across species. Biochem. Pharmacol., 80:1033-1041, 2010 Cited by PubMed: 20599788DOI: 10.1016/j.bcp.2010.06.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report