3N7O

X-ray structure of human chymase in complex with small molecule inhibitor.

3N7O の概要

• エントリーDOI: 10.2210/pdb3n7o/pdb
• 分子名称: Chymase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, (S)-[(1S)-1-(5-chloro-1-benzothiophen-3-yl)-2-{[(E)-2-(3,4-difluorophenyl)ethenyl]amino}-2-oxoethyl]methylphosphinic acid, ... (5 entities in total)
• 機能のキーワード: serine protease, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26300.47

構造登録者

Abad, M.C.,Kervinen, J.,Crysler, C.,Bayoumy, S.,Spurlino, J.,Deckman, I.,Greco, M.N.,Maryanoff, B.E.,Degaravilla, L. (登録日: 2010-05-27, 公開日: 2010-07-21, 最終更新日: 2023-09-06)

• 主引用文献: Kervinen, J.,Crysler, C.,Bayoumy, S.,Abad, M.C.,Spurlino, J.,Deckman, I.,Greco, M.N.,Maryanoff, B.E.,de Garavilla, L.; Potency variation of small-molecule chymase inhibitors across species.; Biochem. Pharmacol., 80:1033-1041, 2010; PubMed: 20599788; DOI: 10.1016/j.bcp.2010.06.014

実験手法

X-RAY DIFFRACTION (1.8 Å)