3N6S

Crystal structure of human mitochondrial mTERF in complex with a 15-mer DNA encompassing the tRNALeu(UUR) binding sequence

3N6S の概要

• エントリーDOI: 10.2210/pdb3n6s/pdb
• 関連するPDBエントリー: 3N7Q
• 分子名称: Transcription termination factor, mitochondrial, DNA (5'-D(*AP*TP*GP*GP*CP*AP*GP*AP*GP*CP*CP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*CP*GP*GP*GP*CP*TP*CP*TP*GP*CP*CP*A)-3') (3 entities in total)
• 機能のキーワード: mitochondrial transcription termination factor-dna complex, mitochondrial replication pausing-dna complex, left-handed helical tandem repeat, protein-dna complex, transcription, replication-dna complex, replication/dna
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion: Q99551
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 49830.01

構造登録者

Jimenez-Menendez, N.,Fernandez-Millan, P.,Rubio-Cosials, A.,Arnan, C.,Montoya, J.,Jacobs, H.T.,Bernado, P.,Coll, M.,Uson, I.,Sola, M. (登録日: 2010-05-26, 公開日: 2010-06-16, 最終更新日: 2024-02-21)

主引用文献

Jimenez-Menendez, N.,Fernandez-Millan, P.,Rubio-Cosials, A.,Arnan, C.,Montoya, J.,Jacobs, H.T.,Bernado, P.,Coll, M.,Uson, I.,Sola, M.
Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat.
Nat.Struct.Mol.Biol., 17:891-893, 2010

PubMed Abstract: The regulation of mitochondrial DNA (mtDNA) processes is slowly being characterized at a structural level. We present here crystal structures of human mitochondrial regulator mTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonucleotides containing the tRNA(Leu)(UUR) gene sequence. mTERF comprises nine left-handed helical tandem repeats that form a left-handed superhelix, the Zurdo domain.

PubMed: 20543826
DOI: 10.1038/nsmb.1859

実験手法

X-RAY DIFFRACTION (3.1 Å)