3N4W
Crystal structure of an abridged SER to ALA mutant of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase ICA512/IA-2 at pH 7.5
Summary for 3N4W
Entry DOI | 10.2210/pdb3n4w/pdb |
Related | 2QT7 3N0I |
Descriptor | Receptor-type tyrosine-protein phosphatase-like N, CALCIUM ION (3 entities in total) |
Functional Keywords | ia-2, ica-512, protein-tyrosine phosphatase, transmembrane protein, diabetes, autoimmunity, proteolysis, glycoprotein, receptor, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane ; Single-pass type I membrane protein . ICA512-transmembrane fragment: Cytoplasmic vesicle, secretory vesicle membrane . ICA512-cleaved cytosolic fragment: Nucleus : Q16849 |
Total number of polymer chains | 2 |
Total formula weight | 19283.91 |
Authors | Primo, M.E.,Jakoncic, J.,Poskus, E.,Ermacora, M.R. (deposition date: 2010-05-23, release date: 2010-12-01, Last modification date: 2023-09-06) |
Primary citation | Primo, M.E.,Klinke, S.,Sica, M.P.,Goldbaum, F.A.,Jakoncic, J.,Poskus, E.,Ermacora, M.R. Structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2. J.Biol.Chem., 283:4674-4681, 2008 Cited by PubMed: 18048354DOI: 10.1074/jbc.M708144200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.45 Å) |
Structure validation
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