3N3K

The catalytic domain of USP8 in complex with a USP8 specific inhibitor

3N3K の概要

• エントリーDOI: 10.2210/pdb3n3k/pdb
• 関連するPDBエントリー: 1WHB 2A9U 2FZP 2GFO
• 分子名称: Ubiquitin carboxyl-terminal hydrolase 8, Ubiquitin, ZINC ION, ... (4 entities in total)
• 機能のキーワード: hydrolase, protease, thiol protease, ubl conjugation pathway, deubiquitinating enzyme, dub, zinc ribbon, inhibitor, ubiquitin, isopeptide bond, nucleus, phosphoprotein, structural genomics, structural genomics consortium, sgc
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm : P40818
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 54751.48

構造登録者

Walker, J.R.,Avvakumov, G.V.,Xue, S.,Li, Y.,Allali-Hassani, A.,Lam, R.,Ernst, A.,Sidhu, S.,Weigelt, J.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Bochkarev, A.,Dhe-Paganon, S.,Structural Genomics Consortium,Structural Genomics Consortium (SGC) (登録日: 2010-05-20, 公開日: 2010-06-23, 最終更新日: 2023-09-06)

• 主引用文献: Ernst, A.,Avvakumov, G.,Tong, J.,Fan, Y.,Zhao, Y.,Alberts, P.,Persaud, A.,Walker, J.R.,Neculai, A.M.,Neculai, D.,Vorobyov, A.,Garg, P.,Beatty, L.,Chan, P.K.,Juang, Y.C.,Landry, M.C.,Yeh, C.,Zeqiraj, E.,Karamboulas, K.,Allali-Hassani, A.,Vedadi, M.,Tyers, M.,Moffat, J.,Sicheri, F.,Pelletier, L.,Durocher, D.,Raught, B.,Rotin, D.,Yang, J.,Moran, M.F.,Dhe-Paganon, S.,Sidhu, S.S.; A strategy for modulation of enzymes in the ubiquitin system.; Science, 339:590-595, 2013; PubMed: 23287719; DOI: 10.1126/science.1230161

実験手法

X-RAY DIFFRACTION (2.6 Å)