3N1V

Human FPPS COMPLEX WITH FBS_01

3N1V の概要

• エントリーDOI: 10.2210/pdb3n1v/pdb
• 関連するPDBエントリー: 3N1W 3N3L 3N45 3N46 3N49 3N5H 3N5J 3N6K
• 分子名称: FARNESYL PYROPHOSPHATE SYNTHASE, (5-chloro-3-methyl-1-benzothiophen-2-yl)acetic acid, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: bisphosphonate; fragment-based screening; transferase; isoprene biosynthesis; cholesterol biosynthesis, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P14324
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40760.24

構造登録者

Rondeau, J.-M. (登録日: 2010-05-17, 公開日: 2010-08-18, 最終更新日: 2024-02-21)

• 主引用文献: Jahnke, W.,Rondeau, J.M.,Cotesta, S.,Marzinzik, A.,Pelle, X.,Geiser, M.,Strauss, A.,Gotte, M.,Bitsch, F.,Hemmig, R.,Henry, C.,Lehmann, S.,Glickman, J.F.,Roddy, T.P.,Stout, S.J.,Green, J.R.; Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery.; Nat.Chem.Biol., 6:660-666, 2010; PubMed: 20711197; DOI: 10.1038/nchembio.421

実験手法

X-RAY DIFFRACTION (2.18 Å)