3MZS

Crystal Structure of Cytochrome P450 CYP11A1 in complex with 22-hydroxy-cholesterol

Summary for 3MZS

Entry DOI	10.2210/pdb3mzs/pdb
Descriptor	Cholesterol side-chain cleavage enzyme, PROTOPORPHYRIN IX CONTAINING FE, (3alpha,8alpha,22R)-cholest-5-ene-3,22-diol, ... (5 entities in total)
Functional Keywords	cyp11a1, cytochrome p450, monooxygenase, side chain cleavage enzyme, cholesterol, cholesterol 20-22-desmolase, steroid metabolism, oxidoreductase, heme
Biological source	Bos taurus (bovine,cow,domestic cattle,domestic cow)
Cellular location	Mitochondrion membrane: P00189
Total number of polymer chains	4
Total formula weight	232784.20
Authors	Stout, C.D.,Annalora, A.,Mast, N.,Pikuleva, I. (deposition date: 2010-05-12, release date: 2010-12-15, Last modification date: 2023-09-06)
Primary citation	Mast, N.,Annalora, A.J.,Lodowski, D.T.,Palczewski, K.,Stout, C.D.,Pikuleva, I.A. Structural Basis for Three-step Sequential Catalysis by the Cholesterol Side Chain Cleavage Enzyme CYP11A1. J.Biol.Chem., 286:5607-5613, 2011 Cited by PubMed: 21159775 DOI: 10.1074/jbc.M110.188433 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation